▶ 주요학력

1991-1995 : 부산대학교 자연과학대학 미생물학과 이학사
1996-1998 : 부산대학교 일반대학원 미생물학과 이학석사 (생화학)
1999-2003 : 부산대학교 일반대학원 미생물학과 이학박사 (생화학)

▶ 전공분야

전공-연구분야 : 해부학 - 신경과학
강의분야 : 인체의 구조와 기능
학위논문 : Mechanism of Cerebrovascular Dysfunction and Gene Therapy in Brain Traumatic Injury and Subarachnoid Hemorrhage

▶ 연구분야

Stroke and neurovascular regulation

▶ 주요경력

Oct 2003 - Oct 2007: Postdoctoral Fellow, Massachusetts General Hospital, Harvard Medical School

Nov 2007 - Feb 2009: Research Professor, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University

Mar 2009 - Feb 2014: Assistant Professor, Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University

Mar 2014 - Feb 2018: Associate Professor, Department of Korean Medical Science, School of Korean Medicine, Pusan National University

Mar 2018 - current: Professor, Department of Korean Medical Science, School of Korean Medicine, Pusan National University

▶ 수상경력

제68회 대한해부학회 한곡학술상 빛날상 (October 31, 2018)

▶ 가입학회

The member of Society for Neuroscience
The member of American Heart Association and American Stroke Association
The member of International Society for Cerebral Blood Flow & Metabolism

▶ 연구실적

[국외전문학술지]

Da Hee Jung, Malk Eun Pak, Hong Ju Lee, Sung Min Ahn, Young Ju Yun, Yong-Il Shin, Hwa Kyoung Shin, Seo-Yeon Lee and Byung Tae Choi, Electroacupuncture on the scalp over the motor cortex ameliorates behavioral deficits following neonatal hypoxia-ischemia in rats via the activation of neural stem cells, Life, 10, 240, 2020 (14 October)

Shakya Rajina, Woo Jean Kim, Jung-Hyun Shim, Kyung-Soo Chun, Sang-Hoon Joo, Hwa Kyoung Shin, Seo-Yeon Lee and Joon-Seok Choi, Isolinderalactone induces cell death via mitochondrial superoxide- and STAT3-mediated pathways in human ovarian cancer cells, International Journal of Molecular Sciences; 21, 7530, 2020 (13 October)

Da Hee Jung, Sung Min Ahn, Malk Eun Pak, Hong Ju Lee, Young Jin Jung, Kibong Kim, Yong-Il Shin, Hwa Kyoung Shin, and Byung Tae Choi, Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD, eLife, 9, e56359, 2020 (21 September)

Hyunha Kim, Ji Seon Seo, Seo-Yeon Lee, Ki-Tae Ha, Byung Tae Choi, Yong-Il Shin, Young Ju Yun and Hwa Kyoung Shin, AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice, Brain Behavior and Immunity; 87, 765-776, 2020 (July 1)

Sung Min Ahn, Da Hee Jung, Hong Ju Lee, Malk Eun Pak, Young Jin Jung, Yong-Il Shin, Hwa Kyoung Shin, and Byung Tae Choi, Contralesional Application of Transcranial Direct Current Stimulation on Functional Improvement in Ischemic Stroke Mice, Stroke; 51(7), 2208-2218, 2020 (July 1)

Jung Hwa Park, Min Jae Kim, Woo Jean Kim, Ki-Dong Kwon, Ki-Tae Ha, Byung Tae Choi, Seo-Yeon Lee* and Hwa Kyoung Shin*, Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models, Cancer Letters; 478, 71-81, 2020 (May 28)

Seokgyu Han, Sein Kim, Zhenzhong Chen, Hwa Kyoung Shin, Seo-Yeon Lee, Hyo Eun Moon, Sun Ha Paek and Sungsu Park, 3D bioprinted vascularized tumor for drug testing, International Journal of Molecular Sciences; 21, 2993, 2020 (April 23)

Malk Eun Pak, Sung Min Ahn, Da Hee Jung, Hong Ju Lee, Ki Tae Ha, Hwa Kyoung Shin and Byung Tae Choi, Electroacupuncture therapy ameliorates motor dysfunction via brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a mouse model of Parkinson’s disease, Journals of Gerontology Series A: Biological Sciences and Medical Sciences; 75(4), 712-721, 2020 (March 9)

Gwang Moo Cho, Seo-Yeon Lee, Jung Hwa Park, Min Jae Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Il Shin, Nam Gyun Kim and Hwa Kyoung Shin, Photobiomodulation using a low-level light-emitting diode improves cognitive dysfunction in the 5XFAD mouse model of Alzheimer’s disease, Journals of Gerontology Series A: Biological Sciences and Medical Sciences; 75(4), 631-639, 2020 (March 9)

Seo-Yeon Lee, Jimin Yang, Jung Hwa Park, Hwa Kyoung Shin, Woo Jean Kim, Su-Yeon Kim, Eun Ju Lee, Injoo Hwang, Choon-Soo Lee, Jaewon Lee and Hyo-Soo Kim, The MicroRNA-92a/Sp1/MyoD Axis Regulates Hypoxic Stimulation of Myogenic Lineage Differentiation in Mouse Embryonic Stem Cells, Molecular Therapy; 28(1), 142-156, 2020 (January 8)

Min Jae Kim, Ki Hyun Park, Ji Yun Lee, Ki-Tae Ha, Byung Tae Choi, Jin Ung Baek, Young Ju Yun, Seo-Yeon Lee and Hwa Kyoung Shin, Weisheng-tang ameliorates acute ischemic brain damage in mice by maintaining blood-brain barrier integrity, Oxidative Medicine and Cellular Longevity; 2019, 4379732, 2019 (December 3)

So Youn Park, Hae Young Kim, Yi Sle Lee, Hye Jin Heo, Hwa Kyoung Shin, Won Suk Lee, Ki Whan Hong and Chi Dae Kim, Augmented improvement of cognition and memory by aripiprazole add-on cilostazol treatment in the chronic cerebral hypoperfusion mouse model, Behavioural Brain Research: 365, 133-140, 2019 (March 6)

Ji Young Hwang, Jung Hwa Park, Min Jae Kim, Woo Jean Kim, Ki-Tae Ha, Byung Tae Choi, Seo-Yeon Lee and Hwa Kyoung Shin, Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model, Cancer Letters; 443, 25-33, 2019 (February 28)

Sung Min Ahn, Yu Ri Kim, Yong-Il Shin, Ki Tae Ha, Seo-Yeon Lee, Hwa Kyoung Shin, and Byung Tae Choi, Therapeutic Potential of a Combination of Electroacupunture and TrkB-Expressing Mesenchymal Stem Cells for Ischemic Stroke, Molecular Neurobiology; 56(1), 157-173, 2019 (Jan 1)

Young Soo Koo, Hyunha Kim, Jung Hwa Park, Min Jae Kim, Yong-Il Shin, Byung Tae Choi, Seo-Yeon Lee and Hwa Kyoung Shin, Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism contributes to post-stroke depression induced in mice by ischemic stroke along with spatial restraint stress, Oxidative Medicine and Cellular Longevity; 2018, 2413841, 2018 (December 30)

Hong Ju Lee, Sung Min Ahn, Malk Eun Pak, Da Hee Jung, Seo-Yeon Lee, Hwa Kyoung Shin, and Byung Tae Choi, Positive effects of α-asarone on transplanted neural progenitor cells in a murine model of ischemic stroke, Phytomedicine; 51:151-161, 2018 (December 1)

Min Jae Kim, Seo-Yeon Lee, Ji Young Hwang, Hyunha Kim, Ki-Tae Ha, Byung Tae Choi, Jin Ung Baek* and Hwa Kyoung Shin*, Pretreatment with Shuanghe-tang extract attenuates postischemic brain injury and edema in a mouse model of stroke: an analysis of medicinal herbs listed in Dongui Bogam, Oxidative Medicine and Cellular Longevity; 2018, 2479602, 2018 (Feb 11)

Hyunha Kim, Young Soo Koo, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Byung Tae Choi, Young Ju Yun, Sae-Won Lee and Hwa Kyoung Shin, Combination of constraint-induced movement therapy with electroacupuncture improves functional recovery following neonatal hypoxic-ischemic brain injury in rats, BioMed Research International; 2018, 8638294, 2018 (Feb 7)

Yu Ri Kim, Sung Min Ahn, Malk Eun Pak, Hong Ju Lee, Da Hee Jung, Yong-Il Shin, Hwa Kyoung Shin, and Byung Tae Choi, Potential benefits of mesenchymal stem cells and electroacupuncture on the trophic factors associated with neurogenesis in mice with ischemic stroke, Scientific Reports; 8: 2044, 2018 (Feb 1)

Malk Eun Pak, Da Hee Jung, Hong Ju Lee, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, and Byung Tae Choi, Combined therapy involving electroacupuncture and treadmill exercise attenuates demyelination in the corpus callosum by stimulating oligodendrogenesis in a rat model of neonatal hypoxia-ischemia, Experimental Neurology; 300, 222-231, 2018 (Feb 1)

Hae In Lee, Sae-Won Lee, Nam Gyun Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Il Shin and Hwa Kyoung Shin, Low-level light emitting diode therapy promotes long-term functional recovery after experimental stroke in mice, Journal of Biophotonics; 10(12): 1761-1771, 2017 (Dec 1)

Hae In Lee, Sae-Won Lee, Nam Gyun Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Il Shin and Hwa Kyoung Shin, Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke, Journal of Biophotonics; 10(11): 1502-1513, 2017 (Nov 1)

Hwa Kyoung Shin, Sae-Won Lee and Byung Tae Choi, Modulation of neurogenesis via neurotrophic factors in acupuncture treatments for neurological diseases, Biochemical Pharmacology; 141, 132-142, 2017 (Oct 1)

Hyunha Kim, Min Jae Kim, Young Soo Koo, Hae In Lee, Sae-Won Lee, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Yong-Il Shin, Byung Tae Choi, Young Ju Yun, and Hwa Kyoung Shin, Histological and functional assessment of the efficacy of constraint induced movement therapy in rats following neonatal hypoxic-ischemic brain injury, Experimental and Therapeutic Medicine; 13(6), 2775-2782, 2017 (June 1)

Ha Neui Kim, Malk Eun Pak, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, and Byung Tae Choi, Comparative analysis of the beneficial effects of treadmill training and electroacupuncture in a rat model of neonatal hypoxia-ischemia, International Journal of Molecular Medicine; 39(6), 1393-1402, 2017 (June 1)

Hae In Lee, Sae-Won Lee, So Young Kim, Nam Gyun Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Il Shin and Hwa Kyoung Shin, Pretreatment with light emitting diode therapy reduces ischemic brain injury in mice through endothelial nitric oxide synthase-dependent mechanism, Biochemical and Biophysical Research Communications; 486(4), 945-950, 2017 (May 13)

Ha Neui Kim, Malk Eun Pak, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, and Byung Tae Choi, Beneficial effects of Jiawei Shenqi-wan and treadmill training on deficits associated with neonatal hypoxic-ischemia in rats, Experimental and Therapeutic Medicine; 13(5), 2134-2142, 2017 (May 1)

Fumiaki Oka, Ulrike Hoffmann, Jeong Hyun Lee, Hwa Kyoung Shin, David Chung, Izumi Yuzawa, Shih-Pin Cehn, Yahya Atalay, Ala Nozari, Kristen Hopson, Tao Qin, Cenk Ayata, Requisite ischemia for spreading depolarization occurrence after subarachnoid hemorrhage in rodents, Journal of Cerebral Blood Flow and Metabolism; 37(5), 1829-1840, 2017 (May 1)

Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin* and Byung Tae Choi*, Anti-depressant effects of aripiprazole augmentation for cilostazol-treated mice exposed to chronic mild stress after ischemic stroke, International Journal of Molecular Sciences; 18(2): 355, 2017 (Feb 8)

Sun Young Lee, Sung Min Ahn, Ziyu Wang, Young Wahn Choi, Hwa Kyoung Shin, and Byung Tae Choi, Neuroprotective effects of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside fromPolygonum multiflorum against glutamate-induced oxidative toxicity in HT22 cells, Journal of Ethnopharmacology; ; 195,64-70, 2017 (Jan 4)

Ha Neui Kim, Chan Hee Gil, Yu Ri Kim, Hwa Kyoung Shin, and Byung Tae Choi, Anti-photoaging properties of the phosphodiesterase 3 inhibitor cilostazol in ultraviolet B-irradiated hairless mice, Scientific Reports; 6: 31169, 2016 (August 3)

Yeon Suk Jung, Jung Hwa Park, Hyunha Kim, So Young Kim, Ji Young Hwang, Ki Whan Hong, Sun Sik Bae, Byung Tae Choi, Sae-Won Lee and Hwa Kyoung Shin, Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice, Acta Pharmacologica Sinica; 37, 1031-1044, 2016 (August 1)

Sung Min Ahn, Ha Neui Kim, Yu Ri Kim, Young Whan Choi, Cheol Min Kim, Hwa Kyoung Shin and Byung Tae Choi, Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia, Journal of Ethnopharmacology; 188, 13-20, 2016 (July 21)

Sung Min Ahn, Yu Ri Kim, Ha Neui Kim, Yong-Il Shin, Hwa Kyoung Shin, and Byung Tae Choi, Electroacupuncture ameliorates memory impairments by enhancing oligodendrocyte regeneration in a mouse model of prolonged cerebral hypoperfusion, Scientific Reports; 6: 28646, 2016 (June 28)

Jung Min Ha, Seung Hoon Baek, Young Whan Kim, Seo Yeon Jin, Hye Sun Lee, Sun Ja Kim, Hwa Kyoung Shin, Dong Hyung Lee, Sang Heon Song, Chi Dae Kim and Sun Sik Bae, Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway, Experimental & Molecular Medicine ; 48(6), e240, 2016 (June 17)

Young Whan Kim, Seung Hoon Baek, Eun Kyoung Kim, Jung Min Ha, Seo Yeon Jin, Hye Sun Lee, Hong Koo Ha, Sang Heon Song, Sun Ja Kim, Hwa Kyoung Shin, Jeongsik Yong, Do-Hyung Kim, Chi Dae Kim and Sun Sik Bae, Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells, FEBS Letters; 590(9), 1365-1374, 2016 (May 1)

Yeon Suk Jung, Sae-Won Lee, Jung Hwa Park, Hyung Bum Seo, Byung Tae Choi and Hwa Kyoung Shin, Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke, Journal of Biomedical Science; 23(1):32, 2016 (March 8)

Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin and Byung Tae Choi, Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke, Psychopharmacology (Berl); 233(6), 1055-1066, 2016 (March 1)

Malk Eun Pak, Yu Ri Kim, Ha Neui Kim, Sung Min Ahn, Hwa Kyoung Shin, Jin Ung Baek and Byung Tae Choi, Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects, Journal of Ethnopharmacology; 179, 383-390, 2016 (February 17)

Hae In Lee, Jung Hwa Park, Min Young Park, Nam Gyun Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Il Shin and Hwa Kyoung Shin, Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice, Restorative neurology and neuroscience; 34(2): 201-214, 2016 (January 20)

Ha Neui Kim, Yu Ri Kim, Sung Min Ahn, Sun Kyung Lee, Hwa Kyoung Shin and Byung Tae Choi, Protease activated receptor-1 antagonist ameliorates the clinical symptoms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood brain barrier, Journal of neurochemistry; 135(3), 577-88, 2015 (Nov 1)

Bo Kyung Kang, Mi Kyoung Kim, So Young Kim, Seung Jin Lee, Young Whan Choi, Byung Tae Choi and Hwa Kyoung Shin, Anti-neuroinflammatory effects of Uncaria sinensis in LPS-stimulated BV2 microglia cells and focal cerebral ischemic mice, The American Journal of Chinese Medicine; 43(6), 1099-1115, 2015 (Sep 14)

Yu Ri Kim, Ha Neui Kim, Malk Eun Pak, Sung Min Ahn, Ki Whan Hong, Hwa Kyoung Shin* and Byung Tae Choi*, Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole, Behavioural Brain Research; 287, 294-303, 2015 (July 1) (*contributed equally)

Sung Min Ahn, Yu Ri Kim, Ha Neui Kim, Young Whan Choi, Jae Won Lee, Cheol Min Kim, Jin Ung Baek, Hwa Kyoung Shin, and Byung Tae Choi, Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia, BMC Complementary and Alternative Medicine ; 15: 202, 2015 (June 30) 

Sung Min Ahn, Yu Ri Kim, Ha Neui Kim, Hwa Kyoung Shin and Byung Tae Choi, Beneficial Effects of Polygonum multiflorum on hippocampal neuronal cells and mouse focal cerebral ischemia, The American Journal of Chinese Medicine; 43(4), 637-651, 2015 (June 28)

Hyung Bum Seo, Bo Kyung Kang, Ji Hyun Kim, Young Whan Choi, Jin Woo Hong, Byung Tae Choi and Hwa Kyoung Shin, Partially purified components of Uncaria sinensis attenuate blood brain barrier disruption after ischemic brain injury in mice, BMC Complementary and Alternative Medicine ; 15: 157, 2015 (May 27)

Min Young Park, Yeon Suk Jung, Jung Hwa Park, Young Whan Choi, Jaewon Lee, Cheol Min Kim, Jin Ung Baek, Byung Tae Choi and Hwa Kyoung Shin, PMC-12, a prescription of traditional Korean medicine improves amyloid β-induced cognitive deficits through modulation of neuroinflammation, Evidence-Based Complementary and Alternative Medicine; 768049, 2015 (April 7)

[국내전문학술지]

[단행본]

[연구보고서]

▶ 특허출원

1. 신용일, 최병태, 신화경, 정영진, 조형택. 침형 전극을 포함하는 경두개 직류 자극(tDCS) 장치. 등록번호 (10-2130198). June 29, 2020

2. 신용일, 김연희, 김민선, 신병철, 최병태, 신화경. 지속적 뇌 자극이 가능한 착용형 두침 및 이를 포함하는 두침 시스템. 출원번호 (10-2016-0167627). Dec 9, 2016

3. 최병태, 백진웅, 신화경. 퇴행성 뇌질환 예방, 개선 또는 치료용 조성물 (Composition for preventing or treatment of neurodegenerative diseases). 등록번호 (10-1793503). Oct 30, 2017

4. 최병태, 신화경, 최영환, 이재원, 김철민, 김영식. 생약재의 추출물을 유효성분으로 포함하는 뇌질환 또는 신경질환의 예방 또는 치료용 조성물 (Composition for preventing or treating brain disease or neural disease comprising oriental herbal extracts). 등록번호 (10-1569813). Nov 11, 2015

5. 최병태, 신화경, 최영환, 이재원, 김철민, 김영식. 백하수오, 건지황, 원지 및 석창포의 혼합추출물을 포함하는 기억 또는 인지 장애 질환의 예방 또는 치료용 조성물 (Composition comprising extract of Cynanchum wilfordii, Rehmannia glutinosa, Polygala tenuifolia and Acorus gramineus for memory or cognition disorder). 등록번호 (10-1519852). May 7, 2015

6. 신화경, 최병태, 최영환. 뇌혈관 질환의 예방 또는 치료용 의약 조성물 및 건강기능식품 (Pharmaceutical composition and health functional food for preparing or treating cerebrovascular diseases). 등록번호 (10-1340408). Dec 5, 2013

7. 신화경, 조수인, 김지현. 뇌졸중 치료용 조성물 (Composition for treating stroke). 등록번호 (10-1247633). Mar 20, 2013