▶ 주요학력

고려대학교 이과대학 생물학과 학사
고려대학교 이과대학 생물학과 미생물학 석사
University of Texas at Austin, Dept.of Microbiology, Ph.D.

▶ 전공분야

Virology
Immunology

▶ 연구분야

1. 급성폐손상 (acute lung injury)에 대한 천연물 치료제 개발 

2. 만성 폐질환에 대한 천연물 치료제 개발

3. 천식 모델 개발과 면역학적 병리기전 연구

▶ 주요경력

Harvard Medical School Postdoctoral fellow
질병관리본부 국립보건원 연구관
Vanderbilt University School of Medicine Research Assistant Professor

▶ 수상경력

국비유학

▶ 가입학회

American Thoracic Society
American Society for Microbiology

American Association of Immunologists

▶ 연구실적

[수행연구과제]

1. 한국연구재단: 급성폐손상에 관한 연구

2. 한국생명공학연구원 협동과제: 천식 치료제 개발 연구 

3. 한국한의학연구원: 육음 중, 한사(寒邪)에 의한 호흡기 감염 및 염증에 미치는 영향 연구

[국외전문학술지]

Estrogen induced β-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells. Choi HJ, Chung TW, Kim CH, Jeong HS, Joo M, Youn B, Ha KT. Biochem Biophys Res Commun. 2012 Sep 6.(12)01719-6.

Curcumin mediated epigenetic modulation inhibits TREM-1 expression in response to lipopolysaccharide. Yuan Z, Syed MA, Panchal D, Rogers D, Joo M, Sadikot RT. Int J Biochem Cell Biol. 2012 Nov;44(11):2032-43.

Aesculin inhibits matrix metalloproteinase-9 expression via p38 mitogen activated protein kinase and activator protein 1 in lipopolysachride-induced RAW264.7 cells. Choi HJ, Chung TW, Kim JE, Jeong HS, Joo M, Cha J, Kim CH, Ha KT. Int Immunopharmacol. 2012 Nov;14(3):267-74.

PGD synthase and PGD2 in immune response. Joo M , Sadikot RT. Mediators Inflamm. 2012;2012:503128.

Protective effect of the fruit hull of Gleditsia sinesis on LPS-induced acute lung injury is associated with Nrf2 activation. Choi JY, Kwun  MJ, Kim KH, Lyu JH, Han CW, Jeong HS, Ha KT, Jung HJ, Lee BJ, Sadikot RT., Christman JW, Jung SK, and Joo M . Evid Based Complement Alternat Med. 2012;2012:974713-24.

Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products. Baek GH, Jang YS, Jeong SI, Cha J, Joo M , Shin SW, Ha KT, Jeong HS. Inflammation. 2012 Feb 14.

Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB. Lyu JH, Kim KH, Kim HW, Cho SI, Ha KT, Choi JY, Han CW, Jeong HS, Lee HK, Ahn KS, Oh SR, Sadikot RT, Christman JW, Joo M . J Ethnopharmacol. 2012 Mar 6;140(1):107-16. 
 

Ent-Kaur-16-en-19-oic Acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2. Lyu JH, Lee GS, Kim KH, Kim HW, Cho SI, Jeong SI, Kim HJ, Ju YS, Kim HK, Sadikot RT, Christman JW, Oh SR, Lee HK, Ahn KS, Joo M. J Ethnopharmacol. 2011 Oct 11;137(3):1442-9.

MyD88 is a mediator for the activation of Nrf2. Kim KH, Lyu JH, Koo ST, Lee HK, Ahn KS, Sadikot RT, Joo M . Biochem Biophys Res Commun. 2011 Jan 7;404(1):46-51

MyD88 is a mediator for the activation of Nrf2. Kim K, Lyu J, Oh SR, Lee HK, Ahn KS, Sadikot RT, Joo M. Biochem Biophys Res Commun. 2010 in press.

Peptidylarginine deiminase 2 suppresses inhibitory kappa B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. Lee HJ, Joo M, Abdolrasulnia R, Young DG, Choi I, Ware LB, Blackwell TS, Christman BW. J Biol Chem. 2010 Oct 11. [Epub ahead of print]

expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. Syed MA, Joo M, Abbas Z, Rodger D, Christman JW, Mehta D, Sadikot RT. Exp Cell Res. 2010 Nov 15;316(19):3140-9. Epub 2010 Aug 24

NADPH oxidase limits innate immune responses in the lungs in mice. Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. PLoS One. 2010 Mar 16;5(3):e9631

Heng Z, Heiderscheidt CA, Joo M, Gao X, Knezevic N, Mehta D, Sadikot RT. MyD88-dependent and -independent activation of TREM-1 via specific TLR ligands. Eur J Immunol. 2010 Jan;40(1):162-171

Joo M,* Kwon M, Cho YJ, Hu N, Pedchenko TV, Sadikot RT, Blackwell TS, Christman JW. Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L771-9. *Joo is corresponding author

Han W, Joo M, Everhart MB, Christman JW, Yull FE, Blackwell TS.Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L320-7.

Stathopoulos GT, Psallidas I, Moustaki A, Moschos C, Kollintza A, Karabela S, Porfyridis I, Vassiliou S, Karatza M, Zhou Z, Joo M, Blackwell TS, Roussos C, Graf D, Kalomenidis I.A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion. J Natl Cancer Inst. 2008 Oct 15;100(20):1464-76.

Musiek, E.S., Brooks, J.D., Joo, M., Brunoldi, E., Porta, A., Zanoni, G., Vidari, G., Blackwell, T.S., Montine, T.J., Milne, G.L., McLaughlin, B., Morrow. J,D. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem. 2008 Jul.; 283 (29):19927-35

Joo, M. *, Kwon, M., Azim, A.C., Sadikot, R.T., Blackwell, T.S., Christman, J.W. Genetic determination of the role of PU.1 in macrophage gene expression. Biochem Biophys Res Commun. 372(1):97-102, 2008. *Joo is corresponding author

Azim, A.C., Wang, X., Park, G.Y., Sadikot, R.T., Cao, H., Mathew, B., Atchison, M., van Breemen, R.B., Joo,M., and Christman, J. W. NF-k B Inducing Kinase (NIK) regulates COX-2 gene expression in macrophages by phosphorylation of PU.1. J. Immunol. 179 (11):7868-7875, 2007.

Ornatowska, M., Azim, A.C., Wang, X., Joo, M., Christman, J.W., Sadikot, R.T. Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am. J. Physiol. Lung Cell Mol. Physiol. 293(6):L1377-L1384, 2007.

Joo, M.*, Kwon, M., Sadikot, R., Kingsley, P.J., Marnett, L.J., Blackwell, T.S., Peebles, R.S. Jr., Urade, Y., Christman, J.W. Induction and function of lipocalin prostaglandin D synthase in host immunity. J. Immunol.179 (4):2566-2575, 2007. * Joo is corresponding author

Zeng, H., Ornatowska, M., Joo, M., Sadikot, R.T. TREM-1 expression in macrophages is regulated at transcriptional level by NF-kappaB and PU.1. Eur J Immunol. 37(8):2300-2308, 2007

Park, G.Y., Hu, N., Wang, X., Sadikot, R., Yull, F., Joo, M., Peebles, R.S. Jr., Blackwell, T., Christman, J.W. Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. Clinical and Experimental Immunology. 150(2):245-254, 2007.

Azim, A.C., Cao, H., Gao, X., Joo, M., Malik, A.B., Breemen, R.B., Sadikot, R.T., Park, G.Y., Christman, J.W. Regulation of cyclooxygenase 2 expression by small GTPase Rac2 in bone marrow macrophages. Am. J. Physiol. Lung Cell Mol. Physiol. 179(11):7868-7875, 2007.

Joo, M.*, Wright, J.G., Hu, N.N., Sadikot, R.T., Park, G.Y., Blackwell, T.S., Christman, J.W. Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. Am. J Physiol.: Lung Cell Mol. Physiol. 292(5):L1219-L1226, 2007. *Joo is corresponding author

Sadikot, R.T., Zeng, H., Azim, A.C., Joo, M., Dey, S.K., Breyer, R.M., Peebles, R.S., Blackwell, T.S., Christman, J.W. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur. J. Immunol. 37(4):1001-1009, 2007.

Sadikot, R.T., Zeng, H., Joo, M., Everhart, M.B., Sherrill, T.P., Li, B., Cheng, D.S., Yull, F.E., Christman, J.W., Blackwell, T.S. Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. J Immunol. 176:4923-30, 2006.

Wang, Y., Zhu, G., Baron, R.M., Joo, M., Christman, J.W., Silverman, E.S., Riese, R.J., Cernadas, M. PU.1 regulates Cathepsin S expression in professional APCs. J. Immunol. 176:275-283, 2006.

Pedchenko, T.V., Park, G.Y., Joo, M., Blackwell, T.S., Christman, J.W. Inducible binding of PU.1 and interacting proteins to the toll-like receptor 4 promoter during endotoxemia. Am J. Physiol Lung Cell Mol Physiol. 289(3):L429-L437, 2005.

Joo, M.*, Hahn, Y.S., Kwon, M., Sadikot, R.T., Blackwell, T.S., Christman, J.W. Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. J. Virol. 79(12):7648-7657, 2005. * Joo is corresponding author

Park, G.Y., Joo, M., Pechenoko, T., Blackwell, T.S., Christman, J.W. Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. Am. J. Physiol.: Lung Cell. Mol. Physiol. 286 (5):L956-62, 2004.

Joo, M., Park, G.Y., Wright, J.G., Blackwell, T.S., Atchison, M.L., Christman, J.W. Transcriptional regulation of cyclooxygenase-2 gene in macrophages by PU.1. J. Biol. Chem. 279(8):6658-6665, 2004.

[국내전문학술지]

[단행본]

▶ 특허출원

1. 신규한 에스큘린 베타 유도체, 이의 제조방법 및 이를 유효 성분으로 함유하는 염증성 질환의 예방 또는 치료용 약학조성물 (출원번호:1020110097744)

2. 당귀수산의 추출물을 포함하는 염증성 질환예방 및 치료용 조성물 (출원번호:1020120004744)

3. 에스큘레틴 유도체를 포함하는 염증성 질환예방 및 치료용 조성물 (출원번호:1020120054781)

4. 택사 추출물을 유효성분으로 포함하는 염증성 폐질환의 예방 또는 치료용 조성물 (출원번호: 1020120082292)