▶ Research Interests: 

In the last decade, his research has been focused on identifying and characterizing novel molecular pathways in heart failure. One area of particular interest to him is the role of post-translational modification of key proteins involved in cardiac dysfunction. He designed a multi-faceted approach to profile proteins in cardiomyocytes that interact with sarcoplasmic reticulum calcium ATPase (SERCA2a) pump. His efforts have led to the identification of Small Ubiquitin-like Modifier type 1 (SUMO1) as a potentially important target for heart failure therapy.

Current research projects of his group as follows:

·            Identifying SUMO1 modified proteome under physiological and pathological conditions.

·            Understanding the regulation of SUMO1 by microRNAs in the heart.

·            Characterizing the relationship of post-translational acetylation of SERCA2a and their potential as new molecular pathway underpinning physiological dysfunction and heart failure.

·            Defining the role of SUMO1 in Duchenne Muscular Dystrophy.

This research aims to validate the SUMO pathway and its potential therapeutic target for heart failure.