- POSITION
- Professor
- CONTACT
- mkbae@pusan.ac.kr, +82-51-510-8239
- SPHERE
- Microbiology / Molecular Biology / Oral Physiology
- OFFICE
- Oral Physiology Class
Education
B. S. Pusan National University
M. S. Pusan National University
(Thesis: “Identification of genes differentially expressed by hypoxia in hepatocellular carcinoma cells.” )
Ph. D. Pusan National University
(Thesis: “Identification and functional Studies of HIF-1alpha and pVHL interacting proteins ” )
Research and professional experience
Research assistant, Los alamos National laboratory, NM, USA
Researcher, College of Pharmacy, Seoul National University, Seoul, Korea
PostDoc, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
PostDoc, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, MD, USA
Research associate, School of Dentistry, University of Michigan, MI, USA
Professor, Department of Oral Physiology, School of Dentistry, Pusan National University, Pusan, Korea
Professional activities
Scientific societies:
International Association of Dental Research, Full Member
Korean Academy of Dental Research, Director
Korean Society for Molecular and Cellular Biology, Full Member
Society of Korean Vascular Biology and Medicine, Full Member
Honors and awards
1998 Academic Award, Pusan NationaI University, Korea
2012 Best Research Award, Korean Academy of Dental Research, Korea
Research Interests
Oral physiology, Vascular biology
Publication
1. (SCI) Lee JH, Kim DI, Mun H, Lee SK, Park JS, Kim JH, Lee JH, Park YH, Jeon YC, Yoon UC, Bae MK, Jang HO, Wood WG, Yun I. The effect of propoxycaine.HCl on the physical properties of neuronal membranes .Chem Phys Lipids. 2008 Jul;154(1):19-25.
2. (SCIE) Jang HO, Kim JS, Kwon WC, Kim JK, Ko MS, Kim DH, Kim WI, Jeon YC, Chung IK, Shin SH, Chung J, Bae MK, Yun I.The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells. Arch Pharm Res. 2008 Feb;31(2):188-94.
3. (SCI) Kim SR, Bae YH, Bae SK, Choi KS, Yoon KH, Koo TH, Jang HO, Yun I, Kim KW, Kwon YG, Yoo MA, Bae MK.Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells. Biochim Biophys Acta. 2008 May;1783(5):886-95.
4. Kim GC, Min JH, Kim DK, Lee MH, Bae MK, Em KI, Kwak HH, Park BS, Mutational analysis of tumor suppressor gene p53 in human oral squamous carcinoma cell line YD-9, Int. J. Oral Biol. 2007; 32(2): 79-84.
5. (SCI) Park HJ, Kim MN, Kim JG, Bae YH, Bae MK, Wee HJ, Kim TW, Kim BS, Kim JB, Bae SK, Yoon S.Up-regulation of VEGF expression by NGF that enhances reparative angiogenesis during thymic regeneration in adult rat. Biochim Biophys Acta. 2007 Sep;1773(9):1462-72.
6. (SCI) Kim SR, Bae SK, Choi KS, Park SY, Jun HO, Lee JY, Jang HO, Yun I, Yoon KH, Kim YJ, Yoo MA, Kim KW, Bae MK. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem Biophys Res Commun. 2007 May 25;357(1):150-6.
7. (SCI) Lee YH, Park NS, Kwon JD, Park JS, Shin GB, Lee CS, Jung TS, Choi NJ, Yoon JH, Ok JS, Yoon UC, Bae MK, Jang HO, Yun I.Amphiphilic effects of dibucaine HCl on rotational mobility of n-(9-anthroyloxy)stearic acid in neuronal and model membranes. Chem Phys Lipids. 2007 Mar;146(1):33-42.
8. (SCI) Kim SH, Jeong JW, Park JA, Lee JW, Seo JH, Jung BK, Bae MK, Kim KW.Regulation of the HIF-1alpha stability by histone deacetylases. Oncol Rep. 2007 Mar;17(3):647-51.
9. (SCIE) Koo TH, Jun HO, Bae SK, Kim SR, Moon CP, Jeong SK, Kim WS, Kim GC, Jang HO, Yun I, Kim KW, Bae MK.Porphyromonas gingivalis, periodontal pathogen, lipopolysaccharide induces angiogenesis via extracellular signal-regulated kinase 1/2 activation in human vascular endothelial cells.Arch Pharm Res. 2007 Jan;30(1):34-42.
10. Back SY, Kim SR, Hwang JW, Bae MK, Wee HJ, Choi YH, Oh SO, Kim BS, Yoon S, Bae SK, Kim JB. Combined treatment of Trichostatin A and heat shock increased apoptosis in STAT3-dependent astrocytoma cells. J. Korean. Association. Cancer Prevention, 2006; 11(3): 205-10
11. (SCI) Bae SK, Kim SR, Kim JG, Kim JY, Koo TH, Jang HO, Yun I, Yoo MA, Bae MK.Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1. FEBS Lett. 2006 Jul 24;580(17):4105-13.
12. (SCI) Bae MK, Kim SH, Jeong JW, Lee YM, Kim HS, Kim SR, Yun I, Bae SK, Kim KW. Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1. Oncol Rep. 2006 Jun;15(6):1557-62.
13. (SCI) Bae MK, Kim SR, Lee HJ, Wee HJ, Yoo MA, Ock Oh S, Baek SY, Kim BS, Kim JB, Sik-Yoon, Bae SK.Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Biochim Biophys Acta. 2006 Mar;1763(3):282-9.
14. (SCI) Baek SY, Kim SR, Bae MK, Hwang JW, Kim JS, Choi YH, Wee HJ, Kim BS, Kim JB, Yoon S, Bae SK. Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells.Neurosci Lett. 2006 Apr 3;396(3):230-4.
15. (SCI) Kim SH, Park JA, Kim JH, Lee JW, Seo JH, Jung BK, Chun KH, Jeong JW, Bae MK, Kim KW. Characterization of ARD1 variants in mammalian cells. Biochem Biophys Res Commun. 2006 Feb 10;340(2):422-7.
16. (SCI) Pollard SM, Parsons MJ, Kamei M, Kettleborough RN, Thomas KA, Pham VN, Bae MK, Scott A, Weinstein BM, Stemple DL.Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Dev Biol. 2006 Jan 1;289(1):64-76.
17. Jang HO, Hyun CH, Yoon JH, Kang YG, Park SM, Park YS, Park JS, Ok JS, Lee DH, Bae MK, Yun I. The effect of Dibucaine?HCl on the physical properties of neuronal membranes. Journal of Photoscience 2005; 12(2), 67-73.
18. (SCIE) Jang HO, Huh MH, Lee SW, Lee YH, Lee JH, Seo JB, Koo KI, Jin SD, Jeong JH, Lim JS, Bae MK, Yun I.The effect of dimyristoylphosphatidylethanol on the lateral and rotational mobilities of liposome lipid bilayers. Arch Pharm Res. 2005 Jul;28(7):839-47.
19. (SCI) Bae MK, Jeong DK, Park NS, Lee CH, Cho BH, Jang HO, Yun I.The effect of ethanol on the physical properties of neuronal membranes. Mol Cells. 2005 Jun 30;19(3):356-64.
20. (SCI) Bae MK, Jeong JW, Kim SH, Kim SY, Kang HJ, Kim DM, Bae SK, Yun I, Trentin GA, Rozakis-Adcock M, Kim KW. Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha.Cancer Res. 2005 Apr 1;65(7):2520-5.
21. (SCI) Bae SH, Jeong JW, Park JA, Kim SH, Bae MK, Choi SJ, Kim KW. Sumoylation increases HIF-1alpha stability and its transcriptional activity.Biochem Biophys Res Commun. 2004 Nov 5;324(1):394-400.
22. (SCIE) Bae MK, Huh MH, Lee SW, Kang HG, Pyun JH, Kwak MH, Jang HO, Yun I. Effects of dopamine HCl on structural parameters of bovine brain membranes. Arch Pharm Res. 2004 Jun;27(6):653-61.
23. Jang HO, Kim DW, Kim BI, Sim HG, Lee YH, Lee JH, Bae JH, Bae MK, Kwon TH, and Yun I. Effects of chlorhexidine digluconate on ratational rate of n-(9-anthroyloxy)stearic acid in model membrane of total lipids extracted from Porphyromonas gingivalis outer membrane. Korean J. Physiol. Pharmacol. 2004; 8, 83-88.
24. Lee SB, Kim KW, Bae MK, Bae MH, Jeong JW, Ahn MY, Kim YJ, Isolation and identification of Ref-1 (redox factor-1) interacting proteins using yeast two-hybrid system J. Life science 2004; 14(1), 26-31.